Platelet aggregation and platelet .ALPHA.-tocopherol.

Gamma tocopherol supplementation prevents exercise induced coagulation and platelet aggregation.

INTRODUCTION: Strenuous exercise in sedentary individuals increases the acute risk of atherothrombotic events and depletes endogenous antioxidants. Supplementation with the antioxidant tocopherol ameliorates the risk; however it is unclear whether α-tocopherol, γ-tocopherol or a combination of both is more efficacious. We therefore measured the effects of γ-,αand mixed tocopherol supplementatio...

Alpha-tocopherol, an effective inhibitor of platelet adhesion.

Platelet adhesiveness was tested ex vivo in a group of six normal individuals receiving varying doses of alpha-tocopherol. Adhesion to glass slides coated with fibronectin, collagen, fibrinogen, or plasma proteins was studied by perfusing platelet-rich plasma through a flow chamber that allowed time- and space-resolved observations of platelet adhesion. Platelet adherence was measured in an are...

Platelet lipid composition and platelet aggregation

Abnormal plasma lipoproteins in patients with liver disease are associated with an increase in erythrocyte cholesterol concentration and a raised erythrocyte cholesteroVphosphoEpid molar ratio. We hypothesized that their platelets would also have an increased cholesteroVphospholipid ratio and that this might affect aggregation in vitro. Platelet aggregation by adrenaline and ADP was measured in...

Platelet aggregation, platelet serotonin and pancreatitis.

Platelet Phagocytosis and Aggregation

The addition of latex particles to native (no anticoagulant) or citrated human platelet-rich plasma (PRP), or to a once-washed platelet suspension causes platelet aggregation. This aggregation is associated with phagocytosis of the latex particles by the platelets and appears to be due to release of adenosine diphosphate (ADP) from the platelets. Adenosine and adenosine monophosphate, which are...